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. 2021 Aug 31;5(4):pkab072. doi: 10.1093/jncics/pkab072

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Hazard ratios (HR) for risk of ductal carcinoma in situ of the breast associated with supplemental calcium plus vitamin D (CaD) according to selected baseline characteristics. The error bars represent the 95% confidence intervals (CIs). The analyses were stratified by age, hormone therapy trial arm participation, dietary trial arm participation, and previous breast biopsy. The analyses were stratified by trial phase (time-dependent). Physical activity (metabolic equivalent-hours/week [MET-h/wk]) tertiles (tt) cutoffs: tt0 = 0; tt1 = 0.50-5.33; tt2 = 5.38-14.17; tt3 = 14.25-134.17. Gail model risk of breast cancer tertiles cutoffs: tt1 = 0.37-1.24; tt2 = 1.25-1.74; tt3 = 1.75-12.97. BMI = body mass index; CaD = calcium plus vitamin D; HRT = hormone replacement therapy.