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. 2021 Jul 28;2021(7):CD015017. doi: 10.1002/14651858.CD015017.pub2

Podder 2020.

Study characteristics
Methods
  • Trial design: open‐label RCT with 2 parallel arms

  • Type of publication: journal publication

  • Setting: outpatient

  • Recruitment dates: May to July 2020

  • Country: Bangladesh

  • Language: English

  • Number of centres: 1

  • Study purpose (treatment, prevention): treatment

  • Trial registration number: NA

  • Date of registration: NA

Participants
  • Number of participants (randomized/analyzed): 82/62

  • Age (mean): overall 39 (SD 12.07) years

  • Males, n: overall 44 (71%)

  • Severity of condition according to study definition: outpatients with mild‐to‐moderate disease

  • Severity of condition according to WHO scale: 2 to 3

  • Co‐morbidities: NR

  • Virus detection performed at baseline (test‐positive at baseline): RT‐PCR (100%)

  • Inclusion criteria: RT‐PCR positive; mild‐to‐moderate COVID‐19; aged > 18 years; either sex

  • Exclusion criteria: known pre‐existing hypersensitivity to ivermectin; pregnant and lactating mothers; receiving other antimicrobials or hydroxychloroquine

Interventions
  • Details of intervention

    • Type and dose: ivermectin 0.2 mg/kg, single dose

    • Route of administration: oral

  • Treatment details of control group

    • No treatment except standard of care

  • Concomitant therapy: standard of care including antipyretics, cough suppressants, and capsule doxycycline (100 mg every 12 hours for 7 days) administered in both study arms

  • Duration of follow‐up: until symptom resolution

  • Treatment cross‐overs: none

Outcomes
  • Primary study outcome

    • Not defined

  • Relevant review outcomes reported

    • Duration to symptom resolution (from enrolment)

    • Viral clearance at 10 days

  • Additional study outcomes reported

    • Duration of individual symptoms (fever, cough, shortness of breath, myalgia, fatigue)

    • Duration to symptom resolution (from illness onset)

Notes
  • Date of publication: July 2020

  • Sponsor/funding: 'self financed'

  • Information on ethics votum: no name of responsible ethics committee, reference number of proposal, or votum provided in publication. Sent author request; no response received