Hosseini 2021.

Methods	Trial design: open‐label RCT with 2 parallel arms Type of record: trial register entry and published protocol Sample size: 120 Setting: inpatient and outpatient Country: Iran Language: English Number of centres: 1 Study purpose (treatment, prevention): treatment Trial registration number: IRCT20200506047323N6 Date of registration: 17 November 2020
Participants	Inclusion criteria Age ≥ 20 years old Weight ≥ 35 kg Positive PCR test for COVID‐19 Non‐hospitalized people with mild COVID‐19 as well as hospitalized (≤ 48 hours) people with moderate COVID‐19 Signed informed consent voluntarily and knowingly Exclusion criteria Severe and critical pneumonia due to COVID‐19 Underlying diseases, including AIDS, asthma, loiasis, and severe liver and kidney disease Use of anticoagulants (e.g. warfarin) and angiotensin‐converting enzyme inhibitors (e.g. captopril) History of drug allergy to ivermectin Pregnancy or breastfeeding
Interventions	Details of intervention Type and dose: ivermectin 0.2 mg/kg, single dose Route of administration: oral Treatment details of control group No treatment except standard of care according to patient setting Concomitant therapy Outpatients: standard of care including hydroxychloroquine administered in both study arms Inpatients: standard of care including lopinavir/ritonavir and interferon beta‐1a administered in both study arms
Outcomes	Primary study outcome Length of hospital stay within 7 days Need for ICU within 7 days Need for mechanical ventilation within 7 days For outpatients only: need for hospitalization within 7 days Relevant review outcomes planned For outpatients: incidence of serious adverse reactions within 7 days Additional study outcomes For inpatients: incidence of serious adverse reactions within 7 days
Notes	Reason for awaiting classification: study completed, but results not published yet Recruitment status: completed Prospective completion date: 25 February 2021 Date last update posted: 17 November 2020 Sponsor/funding: Bandare‐abbas University of Medical Sciences