| Entrenas Castillo 2020 |
Some concerns |
Participants were randomize in a 2:1 ratio through an electronically‐generated list, to receive standard treatment coupled with vitamin D or standard treatment alone and the allocation sequence was probably not concealed, as this list was accessible to "study specialists". There are no baseline differences that would suggest a problem with randomization. |
Low risk of bias |
Both participants and those delivering the intervention were aware of intervention received, but there were no deviations from intended interventions and the analysis was appropriate. |
Low risk of bias |
Data for this outcome was available for all 76 participants randomized. |
Low risk of bias |
The measurement of the outcome was appropriate and it is unlikely that it differed between intervention groups. The outcome assessors were probably unaware of the intervention received. |
Some concerns |
For this outcome, there was no information on whether the data that produced this result was analysed in accordance with the predefined protocol, as it was unclear how long patients were followed and how outcome was defined and the protocol was not available. |
Some concerns |
For this outcome there is a low risk of bias due to deviations from intended interventions, due to missing outcome data and in measurement of the outcome. However, there are some concerns for bias from the randomization process and in selection of the reported result. |
| Murai 2021 |
Low risk of bias |
Participants were randomized via computer‐generated random numbering in a 1:1 ratio to receive either a single dose of vitamin D3 or placebo and the allocation sequence was concealed. There are no baseline differences that would suggest a problem with randomization. |
Low risk of bias |
Both participants and those delivering the intervention were unaware of the assigned intervention received and the analysis was appropriate. |
Low risk of bias |
Data for this outcome was available for all 240 participants randomized. |
Low risk of bias |
The measurement of the outcome was appropriate and it is unlikely that it differed between intervention groups. The outcome assessors were unaware of the intervention received. |
Low risk of bias |
The data that produced this result was analysed in accordance with the pre‐specified outcomes reported in the trial registry. |
Low risk of bias |
For this outcome, there is a low risk of bias for all the domains. |
