FIGURE 4.

MMP2 expression positively associates with TSP4 and poor survival rate. A and B, Correlations among TSP4 (THBS4), MMP‐2, and MMP9 expression levels in BC samples analysed using the GEPIA2 web server. C, Overall survival rates in patients with BC with high and low MMP2 expression levels were analysed using the Human Protein Atlas web server. The 406 patients were divided based on the level of FPKM (number Fragments Per Kilobase of exon per Million reads) expression into high and low MMP2 expression groups. The cut‐off value was set to 68.82. D, The correlation between TSP4 and gabapentin receptor α2δ–1 (CACNA2D1) expression level in BC samples analysed using the GEPIA2 web server. E and F, The GENT2 web server was used to analyse the correlations among CACNA2D1 gene expression, primary tumour status, and tumour grade. All data are expressed in terms of the mean ± the SD of triplicate samples. *P < .05, **P < .01, ***P < .001 relative to the control group