Fig. 2.

Longitudinal assessment of liver function. A. Transaminases and alkaline phosphatase. B. Total, direct, and indirect bilirubin. In both panels, the line represents the locally estimated scatterplot smoothing. Relevant clinical features and interventions are shown chronologically. GOT: glutamic-oxaloacetic transaminase; GPT: glutamic pyruvic transaminase; ANAs: anti-nuclear antibodies; ENAs: extractable nuclear antigens antibodies; dsDNA: anti-double stranded DNA antibodies; ANCAs: anti-neutrophil cytoplasmic antibodies; SMA: smooth muscle antibodies; AMA-M2: anti-mitochondrial antibodies type 2; LKM1: liver kidney microsome type 1 antibodies; LC1: Anti-liver cytosolic antigen type 1; SLA: soluble liver antigen antibodies; ECRP: endoscopic retrograde cholangiopancreatography.