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. 2021 Aug 30;18:188. doi: 10.1186/s12974-021-02226-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — OZ treatment reduces neuronal pyroptosis after SAH. a Double immunostaining of NeuN and GSDMD and b quantitative analysis of GSDMD-positive neurons in ipsilateral cortex 24 h after SAH. Scale bar: 20 μm. c Immunoblot analysis of GSDMD expression in the treated mice. d Representative transmission electron micrographs of neurons in brain tissues. Red arrowhead: membrane pores. Scale bar: 2 μm. e The levels of IL-β and IL-18 in the ipsilateral cortex were analyzed by ELISA kits. f Western blot and quantitative analysis of GSDMD in the Control, OxyHb, and OxyHb+OZ groups. g The concentration of IL-1β and IL-18 in the supernatant of the cell culture. Data are expressed as mean ± SD, n = 5 per group. ***P < 0.001 vs Sham group; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs SAH+Vehicle group. ^†††P < 0.001 vs Control group; ^§P < 0.05, ^§§P < 0.01, ^§§§P < 0.001 vs OxyHb group