Table 2.
KEGG pathway analysis of differentially expressed genes associated with pancreatic cancer
| Pathway ID | Name | Count | % | P value | Benjamini P value | Genes | Total numbera | |
|---|---|---|---|---|---|---|---|---|
| Up-regulated | ||||||||
| hsa04610 | Complement and coagulation cascades | 17 | 3.94 | 1.71E−11 | 3.17E−09 | PLAT, C1QA, C3AR1, C1QB, CD55, FGG, C5AR1, C3, F3, SERPINE1, CFH, C1R, C1S, PROS1, C1QC, PLAU, F2R | 78 | |
| hsa05150 | Staphylococcus aureus infection | 15 | 3.47 | 6.53E−11 | 6.07E−09 | C3AR1, C5AR1, HLA-DRB1, C3, FPR1, C1R, ITGB2, C1S, HLA-DMA, C1QC, C1QA, C1QB, FGG, CFH, FCGR3B | 39 | |
| hsa04512 | ECM-receptor interaction | 16 | 3.7 | 6.19E−09 | 3.84E−07 | COL4A2, COL4A1, TNC, COL3A1, ITGA2, ITGA3, COL5A1, LAMB3, SDC1, COMP, COL1A2, LAMC2, THBS2, COL11A1, FN1, THBS4 | 60 | |
| hsa04145 | Phagosome | 19 | 4.4 | 9.18E−08 | 4.27E−06 | ACTB, HLA-DRB1, NCF2, C3, ITGA2, C1R, COLEC12, ITGB2, HLA-B, CTSS, HLA-DMA, COMP, TAP1, TUBA4A, THBS2, FCGR3B, CD14, TUBA1C, THBS4 | 95 | |
| hsa04510 | Focal adhesion | 20 | 4.63 | 1.84E−06 | 6.83E−05 | ACTB, COL4A2, COL4A1, TNC, COL3A1, ITGA2, ITGA3, FLNA, COL5A1, VEGFC, LAMB3, RAC2, COMP, COL1A2, LAMC2, PDGFC, THBS2, COL11A1, FN1, THBS4 | 100 | |
| hsa05146 | Amoebiasis | 13 | 3.01 | 2.08E−05 | 6.45E−04 | COL4A2, LAMB3, COL4A1, COL3A1, COL1A2, SERPINB2, LAMC2, ITGB2, SERPINB3, COL11A1, CD14, COL5A1, FN1 | 69 | |
| hsa05133 | Pertussis | 11 | 2.55 | 2.47E−05 | 6.57E−04 | C1QA, C1QB, GNAI1, C3, LY96, PYCARD, ITGB2, C1R, C1S, C1QC, CD14 | 58 | |
| hsa04974 | Protein digestion and absorption | 10 | 2.31 | 4.96E−04 | 0.011 | KCNN4, COL4A2, COL4A1, ATP1B3, COL3A1, COL1A2, COL11A1, COL5A1, COL10A1, SLC7A7 | 56 | |
| hsa04670 | Leukocyte transendothelial migration | 11 | 2.55 | 1.09E−03 | 0.022 | ACTB, CLDN18, RAC2, NCF2, GNAI1, CXCR4, MMP9, CLDN2, ITGB2, RHOH, THY1 | 75 | |
| hsa05222 | Small cell lung cancer | 9 | 2.08 | 1.75E−03 | 0.032 | COL4A2, E2F3, LAMB3, COL4A1, CKS2, ITGA2, LAMC2, ITGA3, FN1 | 74 | |
| hsa04151 | PI3K–Akt signaling pathway | 19 | 4.4 | 4.38E−03 | 0.066 | COL4A2, COL4A1, TNC, COL3A1, ITGA2, ITGA3, IL7R, COL5A1, VEGFC, LAMB3, COMP, COL1A2, LAMC2, PDGFC, THBS2, COL11A1, FN1, THBS4, F2R | 99 | |
| hsa04611 | Platelet activation | 10 | 2.31 | 7.40E−03 | 0.101 | ACTB, FGG, GNAI1, COL3A1, COL1A2, FCER1G, ITGA2, COL11A1, COL5A1, F2R | 89 | |
| hsa05323 | Rheumatoid arthritis | 8 | 1.85 | 8.51E−03 | 0.107 | CTSK, TNFSF13B, HLA-DRB1, CCL20, IL18, ITGB2, HLA-DMA, MMP1 | 63 | |
| hsa05144 | Malaria | 6 | 1.39 | 9.16E−03 | 0.108 | SDC1, IL18, COMP, ITGB2, THBS2, THBS4 | 44 | |
| Down-regulated | ||||||||
| hsa04972 | Pancreatic secretion | 10 | 5.65 | 2.34E−06 | 3.78E−04 | PNLIPRP1, PNLIPRP2, CHRM3, RAB3D, PRSS3, CPA2, CELA2B, PLCB1, SLC4A4, CTRL | 67 | |
| hsa00260 | Glycine, serine and threonine metabolism | 7 | 3.95 | 8.37E−06 | 6.77E−04 | CTH, GATM, GCAT, GAMT, GNMT, PSAT1, CBS | 32 | |
| hsa01230 | Biosynthesis of amino acids | 6 | 3.39 | 2.41E−03 | 0.122 | BCAT1, CTH, MAT1A, PSAT1, GPT2, CBS | – | |
| hsa00280 | Valine, leucine and isoleucine degradation | 5 | 2.82 | 2.89E−03 | 0.110 | BCAT1, ALDH6A1, AOX1, ABAT, ACAT1 | 41 | |
| hsa04146 | Peroxisome | 6 | 3.39 | 3.98E−03 | 0.121 | EPHX2, PXMP2, CRAT, PEX5L, SLC27A2, PEX7 | 71 | |
aTotal number: the number of genes in pathway