Table 3.
Long-term personal exposure to concentrations of air pollutants and risk of AE-IPF. Results reported from logistic regression models: Odds Ratio (OR) & 95% C.I., after adjusting for gender, age, smoking habits, recent FVC, recent DLCO and antifibrotic therapy. a also adjusting for telomere length ratio; b Ο3: also adjusting for PM2.5
| Results reported per (10 μg/m3): | All patients | Patients residing in the Greater Athens Area (n = 66) | Patients residing out of the Greater Athens Area (n = 52) | |||
|---|---|---|---|---|---|---|
|
OR (95% CI) |
p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| 1O3 | 0.60 (0.43 to 0.86) | 0.005** | 0.57 (0.27 to 1.17) | 0.126 | 0.76 (0.28 to 2.06) | 0.590 |
| a 2O3 | 0.27 (0.07 to 1.00) | 0.050 | ||||
| b 1O3 | 0.55 (0.27 to 1.13) | 0.105 | 0.42 (0.10 to 1.81) | 0.245 | 0.78 (0.27 to 2.29) | 0.654 |
| b 2O3 | 0.26 (0.01 to 1.05) | 0.052 | ||||
| 1NO2 | 1.52 (1.15 to 2.00) | 0.003** | 1.58 (0.88 to 2.87) | 0.128 | 3.89 (0.75 to 20.3) | 0.106 |
| a 2NO2 | 2.64 (0.99 to 7.05) | 0.053 | ||||
| 1PM2.5 | 2.21 (1.16 to 4.20) | 0.016* | 2.01 (0.56 to 7.12) | 0.282 | 1.67 (0.08 to 36.5) | 0.743 |
| a 2PM2.5 | 2.78 (0.35 to 22.2) | 0.335 | ||||
| 1PM10 | 2.18 (1.15 to 4.15) | 0.017* | 1.96 (0.57 to 6.71) | 0.285 | 1.93 (0.12 to 29.9) | 0.637 |
| a 2PM10 | 2.35 (0.31 to 17.9) | 0.410 | ||||
Abbreviations: FVC Forced Vital Capacity, DLCO Diffusing Capacity of the lung for carbon monoxide, O3 ozone, PM particulate matter, NO2 nitrogen dioxide
1All patients (n = 118)
2All patients with telomere length ratio measurements (n = 36)
* statistically significant at a = 5%
** statistically significant at a = 1%