Table 4.
Distribution of inflammatory mediators (pg/mL) in AE-IPF and stable patients
| Inflammatory mediators (pg/mL) | Median (IQR) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Whole cohort (n = 93) | Patients residing in the Greater Athens Area (n = 51) | Patients residing out of the Greater Athens Area (n = 42) | |||||||
|
All patients (n = 93) |
AE-IPF (n = 49) |
Stable patients (n = 44) |
All patients (n = 51) |
AE-IPF (n = 32) |
Stable patients (n = 19) |
All patients (n = 42) |
AE-IPF (n = 22) |
Stable patients (n = 20) |
|
| IL-1a | 3.2 (24.3) | 3.2 (38.3) | 3.2 (0.0) | 3.2 (36.6) | 3.2 (102.4) | 3.2 (0) | 3.2 (24.4) | 3.2 (17) | 3.2 (23.8) |
| IL-1b | 2.8 (2.6) | 3.2 (2.6) | 1.3 (2.7) | 3.2 (2.5) | 3.2 (2.3) | 1.4 (2.6) | 1.1 (2.7) | 0.9 (2.8) | 1 (2.7) |
| IL-4 | 0.5 (1.1) | 2 (11.7) | 9.8 (25) | 2 (13.3) | 1.8 (10.8) | 9.8 (29) | 9.7 (19.3) | 10.9 (19.2) | 10.1 (23.5) |
| IL-5 | 7.8 (15.8) | 2 (2.7) | 1.6 (1.5) | 1.8 (3.2) | 2 (3.1) | 1.7 (2.2) | 1.6 (2) | 1.7 (3.6) | 1.5 (1.2) |
| IL-6 | 1.7 (2.2) | 4.3 (9.7) | 1.6 (2.4) | 3.3 (8.9) | 4.3 (13.9) | 2.1 (3.4) | 2.4 (4.5) | 3.9 (6.6) | 1.5 (3.4) |
| IL-8 | 2.8 (5.2) | 10.9 (16.1) | 5.1 (5.8) | 7.3 (10.5) | 10.9 17.3) | 5.4 (5.3) | 6.5 (8.9) | 10.9 (16.5) | 4.7 (5.4) |
| IL-10 | 7.0 (9.4) | 4.7 (8.9) | 4.0 (7.3) | 4.4 (6.8) | 4.5 (8.1) | 4 (6.5) | 4.5 (10.1) | 5.8 (13.8) | 3.9 (7.4) |
| IL-13 | 4.4 (8.1) | 2.1 (5.4) | 0.2 (2.0) | 1.1 (5.4) | 1.7 (5.2) | 0.6 (8.8) | 0.3 (2.6) | 2.7 (11.4) | 0.2 (1.3) |
| MCP-1 | 338.6 (186.6) | 359 (232) | 311 (169) | 324 (209) | 316 (232) | 328 (177) | 3701 (185) | 432 (2601) | 288 (185) |
| MIP-1a | 16.0 (23.7) | 17.5 (25.7) | 10.4 (15.7) | 16.9 (26.9) | 18.1 (29.2) | 11.4 (16.5) | 12.2 (20.6) | 12.9 (26.2) | 9.9 (18.3) |
| MIP-4 | 555.0 (268.5) | 543 (361) | 564 (248) | 615 (352) | 608 (495) | 593 (254) | 504 (209) | 502 (227) | 527 (235) |
| MMP1 | 1691 (2189) | 1998 (3459) | 1185 (1746) | 1878 (2711) | 1938 (3394) | 1690 (2306) | 1476 (2053) | 2032 (3414) | 1067 (1192) |
| MMP7 | 2875 (8070) | 680 (7644) | 8156 (8229) | 548 (8035) | 548 (6729) | 8227 (8612) | 7904 (8070) | 4755 (7690) | 8084 (8097) |
| MMP9 | 71,941 (50,498) | 74,697 (45,764) | 61,817 (44,036) | 76,638 (60,233) | 74,331 (67,302) | 86,489 (60,936) | 59,883 (39,402) | 75,441 (43,656) | 57,949.5 (30,739.2) |
| TNFa | 3.9 (5.1) | 3.9 (5.5) | 3.6 (5.2) | 4 (4.7) | 3.9 (4.1) | 5.1 (4.7) | 3.4 (7.2) | 6.1 (7.9) | 2.6 (3.9) |
| TGFb1 | 6847 (19,363) | 7148 (24,161) | 6202 (15,300) | 7148 (23,122) | 7226 (24,052) | 5583 (12,605) | 5990 (19,013) | 6292 (29,717) | 6481 (15,844) |
| OPN | 25,581 (46,783) | 31,149 (37,819) | 23,534 (54,128) | 23,539 (50,807) | 25,124 (41,382) | 15,113 (60,563) | 27,263 (40,751) | 39,117 (40,684) | 25,620 (69,001) |
AE-IPF Acute Exacerbation of Idiopathic Pulmonary Fibrosis, IQR Inter-quartile range