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. 2021 Aug 30;220(10):e202102146. doi: 10.1083/jcb.202102146

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© 2021 Siu et al.

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Figure 2. — Structures of cellular factors involved in sperm–egg attachment and fusion. (A) Human IZUMO1 is shaped like a boomerang in an unbound state (Protein Data Bank [PDB] accession no. 5F4T). The 4HB, hinge, and IgSF domains are shown in orange, green, and cyan, respectively. (B) Human JUNO (PDB accession no. 5F4Q) belongs to the folate receptor family. (C) The structure of human IZUMO1–JUNO complex (PDB accession no. 5F4E) reveals that JUNO binds to IZUMO1 via the β-hairpin hinge, four residues from the 4HB domain and two from the IgSF domain. (D) Human CD9 (PDB accession no. 6K4J) adopts a conical shape formed by four transmembrane helices (TM1–TM4; blue) and two extracellular loops (SEL, pink; and LEL, red).