Comparison 1. Pramipexole versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 UPDRS ADL scores (part II)			Other data	No numeric data
2 UPDRS motor scores (part III)			Other data	No numeric data
3 UPDRS complications scores (part IV)			Other data	No numeric data
4 UPDRS total score			Other data	No numeric data
5 Hoehn and Yahr stage			Other data	No numeric data
6 Schwab and England scale			Other data	No numeric data
7 Clinician's global impression scale (number with satisfactory or good improvement)	1	78	Peto Odds Ratio (Peto, Fixed, 95% CI)	5.84 [2.40, 14.21]
8 Levodopa dose reduction (mg)	3	579	Mean Difference (IV, Fixed, 95% CI)	114.82 [86.64, 143.01]
9 Off time reduction (hours)	4	611	Mean Difference (IV, Fixed, 95% CI)	1.77 [1.21, 2.34]
10 Dyskinesia rating scale			Other data	No numeric data
11 Adverse events ‐ Nausea	4	668	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.31 [0.89, 1.93]
12 Adverse events ‐ Postural hypotension	4	668	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.44 [0.96, 2.17]
13 Adverse events ‐ Hallucinations	3	599	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.63 [1.61, 4.32]
14 Adverse events ‐ Confusion	1	162	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.03 [0.75, 5.53]
15 Adverse events ‐ Dyskinesia	4	668	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.10 [1.50, 2.94]
16 All cause withdrawal rate	4	669	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.64 [0.44, 0.93]