| Methods |
2‐arm active‐controlled randomised trial, plus a non‐intervention control group. |
| Participants |
101 women were randomised in a hospital setting in India. The population comprised women with 3 or more consecutive miscarriages within the first trimester (up to 12 weeks of gestation) followed by spontaneous conception that was euthyroid, normoprolactinemic. Only women who had not received any medication in the last 3 months were considered. Exclusion criteria comprised women who had a cause for their recurrent miscarriages identified using 1 or more of the following tests: thyroid‐stimulating hormone and antithyroid antibody tests, antiphospholipid antibodies test (anticardiolipin antibodies and lupus anticoagulants immunoglobulin G and M), TORCH (toxoplasmosis, rubella, cytomegalovirus and herpes) tests, paternal and maternal chromosomal analysis, hysterosalpingography, and hysteroscopy to rule out uterine defects, abnormal fasting level of homocysteine, exclusion of diabetes mellitus, and estimation of midluteal serum progesterone to exclude luteal phase defect. |
| Interventions |
10 mg oral dydrogesterone, twice daily versus 100 mg micronized vaginal progesterone, thrice daily. Women without history of recurrent miscarriage in the control group did not receive any progestogen. |
| Outcomes |
The study recorded the following outcomes relevant for this review: miscarriage. |
| Notes |
Evidence of trial documentation and data requested from the corresponding author, but no response was received by the time of publication of this review. |
