NCT02145767.

Study name	Progesterone for the prevention of miscarriage and preterm birth in women with first trimester bleeding: PREEMPT Trial
Methods	2‐arm placebo‐controlled randomised trial.
Participants	Women aged between 18 and 45 years with a live intrauterine singleton pregnancy of <14 weeks by crown‐rump length on ultrasound with documented fetal cardiac activity, and presence of a perigestational (subchorionic) haemorrhage on ultrasound. Exclusion criteria include contraindication to progesterone and any indication for progesterone.
Interventions	Progesterone 200 mg suppository administered vaginally at bedtime until 34 completed weeks of pregnancy versus placebo
Outcomes	Miscarriage (< 20 weeks); preterm birth (< 37 weeks); maternal outcomes; neonatal outcomes; healthcare outcomes
Starting date	December 2014
Contact information	preempttrial@gmail.com
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