Table 1.
Roles of E2F-related miRNAs in regulation of cancer stem cells.
| Cancer stem cell type | E2F with upregulated expression | Related miRNAs | Effects on CSC properties | Ref. No. | |
|---|---|---|---|---|---|
| Induction | Suppression | ||||
| Breast CSCs | E2F1 | miR-20b-5p | Proliferation | (117, 118) | |
| miR-185-3p | Stemness | ||||
| Gastric CSCs | E2F1 | miR-20a | Self-renewal Proliferation | (119, 120) | |
| CML SPCs | E2F1 | miR-183 | Proliferation Survival | (21) | |
| Glioblastoma CSCs | E2F2 | miR‐125b | Proliferation | (121, 122) | |
| Let-7b | |||||
| TNBC CSCs | E2F2 | miR-4319 | Self-renewal Metastasis | (123) | |
| Breast CSCs | E2F2 | miR-638 | Self-renewal | (124) | |
| Proliferation | |||||
| Invasion | |||||
| Lung CSCs | E2F2 | miR-99 | EMT | (125) | |
| Stemness | |||||
| Colon CSCs | E2F3 | miR-449b | Proliferation | (126) | |
| Glioblastoma CSCs | E2F3 | miR128-1 | Proliferation | (127) | |
| Ovarian CSCs | E2F6 | miR‐193a | Stemness | (22, 128) | |
| Liver CSCs | E2F7 | miR-302a/d | Self-renewal | (26) | |
| Proliferation | |||||
| Colon CSCs | E2F7 | miR-199b | Stemness | (23) | |
| 5-FU resistance | |||||