Sikkes 2010.

Study characteristics
Patient Sampling	All consecutive patients diagnosed with probable AD, MCI (mild cognitive impairment) or SMC (subjective memory complaint) whose informant completed an IQCODE were included
Patient characteristics and setting	Alzheimer Centre at a University Hospital in the Netherlands; n = 328
Index tests	IQCODE 16 item, Dutch language
Target condition and reference standard(s)	Clinical dementia diagnosis using NINCDS‐ADRDA
Flow and timing	328 participants included ‐ no record given of numbers screened but not included. Informants completed IQCODE while participants were assessed for clinical diagnosis and this was done independently of IQCODE result
Comparative
Notes
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	No
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	No
Could the selection of patients have introduced bias?		High risk
Are there concerns that the included patients and setting do not match the review question?			High
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Could the reference standard, its conduct, or its interpretation have introduced bias?		Low risk
Are there concerns that the target condition as defined by the reference standard does not match the question?			Low concern
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Yes
Were all patients included in the analysis?	Yes
Could the patient flow have introduced bias?		Low risk