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. 2021 Aug 8;2021(8):CD012720. doi: 10.1002/14651858.CD012720.pub2

Miccinilli 2018.

Study characteristics
Methods Study design: monocentric prospective double‐blind randomised controlled trial
Setting: outpatients who report to the Department of Physical and Rehabilitation Medicine of Campus Bio‐Medico, University of Rome
Timing: between September 2016 and December 2017
Interventions: KT application plus standardised rehabilitative protocol of exercises versus sham KT application plus the same standardised rehabilitative protocol of exercises
Sample size: 42 patients were randomised; 40 participants completed the study. Power calculation was not reported.
Analysis: per‐protocol analysis was executed. 
Participants Criteria for defining the condition being treated: radiologic diagnosis of rotator cuff tendinopathy (RoCT) with evidence of pathognomonic signs at musculoskeletal echography or magnetic resonance; clinical positivity to at least one of the specific shoulder tests for RoCT shoulder pain

Exclusion criteria: total tendon lesion; previous fracture or shoulder dislocation; presence of skin lesions contraindicating the application of KT; coexisting elbow, forearm, wrist, hand and fingers pathologies; history of neoplasm; cognitive impairment (MMSE < 24); diabetes mellitus; statin use; diagnosis of anxiety‐depressive syndrome

Baseline characteristics:
Intervention: Kinesio Taping (KT)
Number randomised: 21
Number included in analyses: 21
Age: 61 ± 12 years
Sex: M 9; F 12
Diagnosis: rotator cuff tendinopathy
Median (IQR) pain (NRS 0‐10): 3 (1‐3)
Median (IQR) function (Constant score): 44 (40‐53)
Control: Sham Taping (ST)
Number randomised: 21
Number included in analyses: 19
Age: 64 ± 10 years
Sex: M 9; F 10
Diagnosis: rotator cuff tendinopathy
Median (IQR) pain (NRS 0‐10): 2 (1‐3.5)
Median (IQR) function (Constant score): 42 (38‐51.5)
Pretreatment group differences: no between‐group differences were observed. 
Interventions Intervention: KT
Tape: not reported; taping method: Kase protocol; target: deltoid, glenohumeral articulation, rhomboid; number of applications: 6; single application duration: 2 dd; provider: physiotherapist
Co‐interventions:
10 sessions of rehabilitative treatment, from Monday to Friday for two consecutive weeks, consisting of:
  • ROM improvement exercises

  • Stretching exercises

  • Strengthening of shoulder muscle


Control: ST
Decompressive deltoid‐like application, functional‐like application and a rhomboid‐like application. Taping was positioned without tensioning, with limb in neutral position, without joint involvement (exclusion of the humeral head for the deltoid‐like application, exclusion of the vertebral column for the rhomboid‐like application)
Co‐interventions:
10 sessions of rehabilitative treatment, from Monday to Friday for two consecutive weeks, consisting of:
  • ROM improvement exercises

  • Stretching exercises

  • Strengthening of shoulder muscle

Outcomes Measures pre/post‐treatment:
  • Function: 100‐point Constant Murley score

  • Pain

    • on motion: numerical pain rating scale (NPRS) (0‐10)

    • at rest: numerical pain rating scale (NPRS) (0‐10)

  • Muscle strength: Medical Research Council (MRC) scale


Outcomes used in this review
The following outcomes were considered at the end of treatments:
  • Pain

  • Function (Constant score). Direction of the scale has been changed.

  • Muscle Strength

Notes Funding: not reported
Conflict of interest: not reported
Trial registration: not reported
Adverse events: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk "subjects were randomly assigned to two groups by another examiner using the envelope system (1:1)". Insufficient information for judgement
Allocation concealment (selection bias) Low risk "subjects were randomly assigned to two groups by another examiner using the envelope system (1:1)". Insufficient information for judgement
Blinding of participants (performance bias) Unclear risk "The examiner was blind to real/sham taping treatment. However, the blinding of participants was unclear".
Blinding of personnel (performance bias) High risk "Even if the physiotherapist involved in rehabilitative treatment was blind to the type of taping application, the application of KT can be recognized for shaping application".
Blinding of outcome assessment (detection bias)
self‐reported outcomes Unclear risk "The examiner was blind to real/sham taping treatment. However, the blinding of participants was unclear".
Blinding of outcome assessment (detection bias)
assessor‐reported outcomes Low risk The examiner was blind to real/sham taping treatment.
Incomplete outcome data (attrition bias)
All outcomes Low risk No high percentage and unbalanced loss to follow‐up. No information for intention‐to‐treat analysis
Selective reporting (reporting bias) High risk No protocol published; discrepancy between Methods and Results sections in outcomes declared
Unequal use of co‐intervention Low risk KT with co‐intervention versus sham taping with the same co‐intervention