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. 2021 Aug 31;40:274. doi: 10.1186/s13046-021-02083-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — SHOX2 plays an important role in breast cancer metastasis. (a) The knockdown effect of specific shRNAs on SHOX2 expression in MDA-MB-231 cells. (b) The effect of SHOX2 knockdown on migration and invasion of MDA-MB-231 cells. Representative images and quantitative data are shown in the left and right panels, respectively. (c, d) The effect of SHOX2 knockdown on breast tumor growth in MDA-MB-231-bearing NSG mice (n = 5 mice/group). Tumor weight and growth curves are shown in (c) and (d), respectively. (e, f) The effect of SHOX2 knockdown on breast tumor lung metastasis in MDA-MB-231-bearing NSG mice. The number of nodules on the lung surface and metastasis index measured on H&E-stained lung sections are shown in (e) and (f), respectively. shGFP: the control shRNA against GFP; shSHOX2-1 and shSHOX2-2: two shRNAs targeting different sequences of SHOX2. ^*p < 0.05, ^**p < 0.01