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. 2021 Aug 31;40:274. doi: 10.1186/s13046-021-02083-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — STAT3 cooperates with SHOX2 to promote WASF3 gene transcription. (a) The accumulation of SHOX2 on the WASF3 promoter was determined by ChIP-QPCR assays in MDA-MB-231 and T47D cells. (b) The effect of 20 ng/ml IL6 on the expression of WASF3 and SHOX2 in T47D cells. (c) The effect of SHOX2 overexpression on WASF3 and STAT3 expression and phosphorylation in T47D cells. (d) The effect of STAT3 knockdown (shSTAT3-1 and shSTAT3-2) on WASF3 expression in SHOX2 overexpressing T47D cells. (e) The effect of 50 µM S3I-201 on WASF3 expression in SHOX2 overexpressing T47D cells. ^*p < 0.05, ^**p < 0.01