Table 2.

Histologic comparison between congenital hepatic fibrosis (CHF) and its mimics

Histologic parameters		CHF (n=13)	Mimics (n=6)	P-value
Biliary changes	Bile ductular-like proliferation	13	3	<0.05
	Dilated duct at the center	12	3	N.S.
	Linear lining of ectatic bile ducts along the limiting plate	12	1	<0.01
	Bile ducts crossing limiting plates	9	1	N.S.
	Bile duct fusion and anastomosing	11	2	<0.05
	VMC/VMC-like structures	6	0	N.S.
	Cholangitis (lymphocytic or neutrophilic)	10	2	N.S.
	Bile duct loss (% loss)	0	1 (68% loss)	N.S.
Vascular changes	Portal vein obliteration/hypoplasia	13	6	N.S.
	Portal vein dilation/herniation	0	6	<0.001
	Arterial hyperplasia	13	6	N.S.
	Nodular regenerative hyperplasia	1	4	<0.05
Cholestasis	Bile plugs in bile ducts and ductules	6	0	N.S.
	Bile plugs in canaliculi (lobular cholestasis)	1	0	N.S.
	Hepatocytic cholestasis	1	0	N.S.
	Bile infarcts	0	0	N.S.
	Cholate stasis	0	0	N.S.
Inflammation	Portal inflammation	7	1	N.S.
	Interface hepatitis	0	0	N.S.
	Lymphoid aggregates	2	0	N.S.
Fibrosis	Portal tract expansion with fibrosis	13	1	<0.05
Fibrosis stage: Ludwig (0-4)	Stage 1 (portal fibrosis)	1	1	N.S.
	Stage 2 (periportal fibrosis)	3	3
	Stage 3 (bridging fibrosis)	6	1
	Stage 4 (cirrhosis)	3	1