Table 1.
Characteristics at baseline of patients aged ≥ 75 years with atrial fibrillation included in the CPRD between 2003 and 2017
| No OAC (n = 66,859) |
Incident OAC (n = 47,916) |
Prevalent OAC (n = 50,821) |
|
|---|---|---|---|
| Median age in years (IQR) | 84 (79–89) | 80 (77–84) | 77 (75–82) |
| 75–79 | 19,417 (29.0) | 22,001 (45.9) | 31,543 (62.1) |
| 80–84 | 16,999 (25.4) | 15,079 (31.5) | 10,741 (21.1) |
| 85–89 | 16,442 (24.6) | 8161 (17.0) | 6011 (11.8) |
| 90+ | 14,001 (20.9) | 2675 (5.6) | 2526 (5.0) |
| Sex (female) | 40,029 (59.9) | 24,482 (51.1) | 24,461 (48.1) |
| Median weight in kg (IQR) | 69 (59–80) | 75 (65–86) | 76 (66–88) |
| Median body mass index (IQR) | 25.3 (22.4–28.6) | 26.9 (24.1–30.2) | 26.8 (23.9–30.2) |
| Mean CHA2DS2-VASc score (SD) | 4.2 (1.4) | 4.1 (1.3) | 4.5 (1.5) |
| Mean HAS-BLED score (SD) | 3.3 (1.2) | 3.4 (1.3) | 3.0 (1.2) |
| Co-morbidities at study entry | |||
| Heart failure | 12,415 (18.6) | 5116 (10.7) | 13,307 (26.2) |
| Diabetes mellitus | 10,158 (15.2) | 7829 (16.3) | 10,053 (19.8) |
| Hypertension | 38,630 (57.8) | 31,845 (66.5) | 31,123 (61.2) |
| Ischaemic stroke, transient ischaemic attack, or thromboembolism | 13,084 (19.6) | 7805 (16.3) | 14,708 (28.9) |
| Coronary artery disease | 17,439 (26.1) | 12,248 (25.6) | 15,566 (30.6) |
| Peripheral vascular disease | 6349 (9.5) | 4194 (8.8) | 6568 (12.9) |
| Fragility fracture | 13,453 (20.1) | 7198 (15.0) | 7097 (14.0) |
| Heart valve replacement or mitral stenosis | 738 (1.1) | 626 (1.3) | 3072 (6.0) |
| Dementia | 6649 (9.9) | 909 (1.9) | 1998 (3.9) |
| Chronic renal impairment | 13,141 (19.7) | 11,681 (24.4) | 10,784 (21.2) |
| Acute kidney injury | 1214 (1.8) | 2969 (6.2) | 2298 (4.5) |
| Previous bleed (any) | 22,500 (33.7) | 16,857 (35.2) | 19,333 (38.0) |
| Major bleed | 2667 (4.0) | 1169 (2.4) | 1728 (3.4) |
| Clinically relevant non-major bleed | 20,825 (31.1) | 16,161 (33.7) | 18,349 (36.1) |
| Intracranial haemorrhage | 1340 (2.0) | 378 (0.8) | 649 (1.3) |
| Gastrointestinal bleeding | 8172 (12.2) | 5939 (12.4) | 6086 (12.0) |
| Other bleed | 22,500 (33.7) | 16,857 (35.2) | 19,333 (38.0) |
| One or more falls in past year | 6548 (9.8) | 2258 (4.7) | 2682 (5.3) |
| Mean number of GP encounters in year prior to study entry (SD) | 12.5 (10.9) | 11.7 (9.3) | 17.6 (13.5) |
| Medication prescribed within 3 months of study entry | |||
| Antiplatelets | 38,696 (57.9) | 24,782 (51.7) | 6654 (13.1) |
| Corticosteroids | 4883 (7.3) | 3674 (7.7) | 3159 (6.2) |
| Non-steroidal anti-inflammatories | 4282 (6.4) | 3258 (6.8) | 1259 (2.5) |
| Proton pump inhibitor or H2 receptor antagonist | 21,170 (31.7) | 15,447 (32.2) | 14,810 (29.1) |
| Selective serotonin reuptake inhibitors | 5752 (8.6) | 2329 (4.9) | 3465 (6.8) |
| Statins | 19,113 (28.6) | 20,627 (43.0) | 23,679 (46.6) |
Results are presented as number (%) of patients, median (interquartile range) or mean (standard deviation). GP General practice, CHA2DS2-VASc Stroke risk score, HAS-BLED Bleeding risk score