3.4. Analysis.

Comparison 3: Lay health worker‐led psychosocial interventions versus usual care in treating perinatal depression, Outcome 4: Adverse events

Adverse events
Study	Heading 1
Chibanda 2014	3 participants in pharmacological arm discontinued study drug due to adverse effects.
Fuhr 2019	Overall, 24 (17%) participants in the intervention group and 27 (19%) participants in the control group had at least one serious adverse event; the most common of these events were hospital admissions, experiences of physical violence, and stigmatisation. However, there was no evidence of any differences between the groups.
Lund 2020	There were no significant harms associated with the intervention, and no notable differences between the two arms in the number of adverse events.
Sikander 2019	Overall, 43 (15%) women in the intervention group and 47 (16%) women in the control group had at least one serious adverse event, which were evenly distributed between the groups (p=0·72). The most common serious adverse events were death of the child, hospital admissions (mainly of the child), and experience of physical violence; however, there was no evidence of any difference between the groups.