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. 2016 Aug 23;2016(8):CD010641. doi: 10.1002/14651858.CD010641.pub2

Howard 2010.

Methods Trial design: Randomised cross‐over trial
Intervention setting: Sleep disorders research unit
Shift system: At least one night shift per fortnight during the six months preceding the study (21:00‐07:00)
Follow‐up period (intervention plus follow‐up): 1 night
(Washout period): Minimum of 2 weeks
Participants Inclusion criteria: None reported
Exclusion criteria: Visual impairment that did not correct with eye‐glasses; regularly used sedative medications; history of sleep apnoea or clinical features of sleep apnoea; chronic sleepiness (score greater than 10 on the Epworth Sleepiness Scale)
Number screened: Not reported
Number eligible: Not reported
Number included in our analysis: n = 8
Industry: Sleep research
Age in years: (mean ± SD): 31 ± 9.6
Gender: 75% female
Country: Australia
"Chronotype" or morningness/eveningness score: Not reported
Interventions Intervention: Exposure to a nap
Shift‐based timing: Night (on‐shift)
Hours of intervention: 04:00
Dose/frequency/duration: 30 minutes per exposure,1 exposure per night for 1 night
Control/comparison intervention: No‐nap
  • participants were requested not to sleep after 12:00 noon on each day of testing, and have a minimum of 7 hours sleep on the night prior to the session

  • additional control group: nap in the evening, prior to the night shift (not analysed for this review)

Outcomes Outcomes (measurement tool and timing), relevant to current review:
Sleep length off‐shift: Outcome not examined
Sleep quality off‐shift: Outcome not examined
Sleepiness on‐shift:
  • subjective: Karolinska Sleepiness Scale (at baseline visit: 20:15 plus four times during shift: 20:15, 03:45, 04:30, 06:45)

  • objective: Psychomotor Vigilance Task (at baseline visit: 20:15 plus four times during shift: 20:15, 03:45, 04:30, 06:45)

Notes Funding: VicRoads
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk "alternating sequence"
Allocation concealment (selection bias) Unclear risk No information
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Participants were not advised in advance which condition they would be participating in on a given night (of 3 possibilities)
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk No information (see Applicability of design)
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Participants completed all experimental conditions
Selective reporting (reporting bias) Low risk All expected outcomes reported
Outcome reliably or objectively measured Low risk Karolinska Sleepiness Scale; Psychomotor Vigilance Task Test
Other potential sources of bias Unclear risk We deem a 2‐week washout period sufficient to avoid a possible carry‐over effect. However, no main effect testing was reported for period effect
Notable: "...sleep inertia...may have played a role in the lack of significant performance improvement following the morning nap in the current study"