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. 2021 Aug 12;15:710820. doi: 10.3389/fncel.2021.710820

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Copyright © 2021 Ling, Wang, Ma, Xue, Gu, Cao and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing Panx 1 inhibits LPS-induced inflammatory cytokine expression in primary cultured astrocytes. (A–E) The effect of Panx 1 downregulation on LPS-induced inflammatory cytokine mRNA expression, including IL-1β, IL-6, TNF-α, TGF-β, and IL-10 in primary cultured astrocytes by qPCR assay. The data were normalized to GAPDH or 18S mRNA levels. (F–H) Evoked expression (content) of IL-1β, IL-6, and IL-10 in astrocytes following with different stimulation, n = 3. All data are mean ± SEM. Statistical comparison for were performed using Student’s t-test. *p < 0.05, ***p < 0.001 compared with negative control siRNA group.