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. 2021 Aug 12;13:714186. doi: 10.3389/fnagi.2021.714186

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Copyright © 2021 Mitra, Turconi, Darreh-Shori, Mätlik, Aquilino, Eriksdotter and Andressoo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression of the key cholinergic enzyme, Chat strongly correlates with the expression of the related genes. Graphs (A–C) show correlations in the cortex, and (D–F) show the correlations in the striatum. Cortex: n = 6 (young Gdnf^wt/wt), n = 5 (old Gdnf^wt/wt), n = 7 (young Gdnf^wt/hyper), n = 6 (old Gdnf^wt/hyper). Striatum: n = 5 (young Gdnf^wt/wt), n = 6 (old Gdnf^wt/wt), n = 6 (young Gdnf^wt/hyper), n = 7 (old Gdnf^wt/hyper). Ache, acetylcholinesterase; Chat, choline acetyltransferase; Cht, choline transporter; M3 mAChR, m3 muscarinic ACh receptor 3; Trka, tropomyosin receptor kinase A.