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. 2021 Aug 12;13:714186. doi: 10.3389/fnagi.2021.714186

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Copyright © 2021 Mitra, Turconi, Darreh-Shori, Mätlik, Aquilino, Eriksdotter and Andressoo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gdnf^wt/hyper mice resist age-related decline in Y-maze test. (A) The spatial recognition memory of Gdnf^wt/wt and Gdnf^wt/hyper mice was assessed with the Y-maze test. (B) Upon aging, the number of alternations was significantly decreased in Gdnf^wt/wt mice, but not in Gdnf^wt/hyper animals. n = 7 (young Gdnf^wt/wt), n = 5 (old Gdnf^wt/wt), n = 6 (young Gdnf^wt/hyper), n = 12 (old Gdnf^wt/hyper). Data are presented as mean ± SEM. *p < 0.05. O, old; Y, young.