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. 2021 Jul 21;2021(7):CD013433. doi: 10.1002/14651858.CD013433.pub2

Wu 2010.

Study characteristics
Methods Study design: RCT
Parallel groups (2)
Open label
Single centre
Country: China
Duration: 24 months
Participants 38 participants (20 SCT vs 18 control)
Period (recruitment): March 2004 to October 2006
Inclusion criteria: diagnosis of DCM by clinical manifestations, echocardiography, and coronary angiography, that excluded coronary atherosclerosis; LVEF < 50%
Exclusion criteria: people with secondary DCM.
Baseline characteristics
  • Sex (male): 76.5%

  • Age (years), range: 42–72

  • LEVF (%), mean: control not reported vs SCT 30.0 (SD 9)

Interventions Intervention group: STC
Details of SCT
  • Cell origin: peripheral blood cells

  • Cell collection location: peripheral blood puncture

  • Type of cells infused: mononuclear, autologous

  • Mean volume/number administered: 2 mL, 8–10 times

  • Cell mobilization: recombinant human G‐CSF 300 pg/day for 5 days

  • Delivery route: IC

  • Number of cell infusions: single


Control group:
  • Usual care (conventional drug treatment without peripheral blood stem cell transplantation)


Study included in Comparison 1 (STC vs control)
Outcomes Outcomes included in the review
  • All‐cause mortality (primary endpoint)

  • Safety

  • 6MWT

  • LVEF (%)


Other outcomes reported
  • Cardiac event rate (atrial premature beat; ventricular premature beat; atrial tachycardia; brachial ventricular tachycardia)

  • LVDD (mm)


Study did not specify which was the primary outcome.
Notes Not registered at ClinicalTrials.gov
Study published in Chinese language.
Funding: not reported.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "Patients were randomly assigned at the intervention and control group." 
No further details are provided.
Allocation concealment (selection bias) Unclear risk No details provided.
Blinding of participants and personnel (performance bias)
All outcomes High risk Open‐label trial.
Blinding of outcome assessment (detection bias)
All outcomes High risk Open‐label trial.
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Apparently, there were no losses or withdrawals. No flow chart provided.
Selective reporting (reporting bias) Unclear risk No protocol reported.