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Summary of activation of Ras-Raf mutants
| Mutant | Phosphorylation
|
% Viability 48 h after IL-3 star-vation | ||
|---|---|---|---|---|
| p42/MAPK | p70/S6K | Akt | ||
| ΔRaf | + | − | NDa | 60 |
| Ras(G12V) | + | + | + | >90 |
| Ras(G12V/T35S) | Weak | − | ND | 10 |
| Ras(G12V/V45E) | − | + | + | 75 |
| Ras(G12V) + rapamycin | + | − | ND | 80 |
| Ras(G12V/V45E) + rapamycin | − | − | ND | <10 |
| Ras(G12V) + wortmannin | + | ND | − | 80 |
| Ras(G12V/V45E) + wortmannin | − | ND | − | <10 |
ND, not done.
