Table 6.
Blood inflammatory biomarkers.
| Biomarker | Day -2 | Day 5 | Day 10 |
|---|---|---|---|
| IL-6 | (Mean ± SD)# | (Mean ± SD) | (Mean ± SD) |
| Control | 5.1 ( ± 5.4) | 6 ( ± 7.5) | 3.2 ( ± 1.9) |
| Foralumab/Dexa | 10.6 ( ± 9.2) | 7.5 ( ± 9.6) | 6.3 ( ± 9.2) |
| Foralumab | 12 ( ± 11.5) | 3.5 ( ± 3) | 3.7 ( ± 2.4) |
| Three group comparison (p-value) | 0.09 | 0.41 | 0.29 |
| Control - Foralumab/Dexa | – | 0.20 | 0.40 |
| †Control - Foralumab | – | 0.01 | 0.031 |
| †Foralumab - Foralumab/Dexa | – | 0.42 | 0.32 |
| CRP | (Mean ± SD) | (Mean ± SD) | (Mean ± SD) |
| Control | 10.4 ( ± 19.6) | 5.8 ( ± 12.8) | 6.2 ( ± 12.2) |
| Foralumab/Dexa | 18 ( ± 25.7) | 7.7 ( ± 22.1) | 8.2 ( ± 15.3) |
| Foralumab | 18.7 ( ± 24.5) | 14.3 ( ± 18.7) | 2.8 ( ± 3.6) |
| Three group comparison (p-value) | 0.56 | 0.44 | 0.52 |
| †Control - Foralumab/Dexa | – | 0.27 | 0.57 |
| †Control - Foralumab | – | 0.87 | 0.032 |
| †Foralumab - Foralumab/Dexa | – | 0.23 | 0.26 |
| D-dimer | (Mean ± SD) | (Mean ± SD) | (Mean ± SD) |
| Control | 368.8 ( ± 156.7) | 888.6 ( ± 1635.6) | 573.5 ( ± 436.8) |
| Foralumab/Dexa | 434.6 ( ± 216.8) | 555.5 ( ± 376.6) | 417.1 ( ± 210.4) |
| Foralumab | 499.5 ( ± 317.3) | 757.7 ( ± 872.5) | 551.8 ( ± 356.5) |
| Three group comparison (p-value) | 0.34 | 0.77 | 0.52 |
| †Control - Foralumab/Dexa | – | 0.34 | 0.35 |
| †Control - Foralumab | – | 0.28 | 0.64 |
| †Foralumab - Foralumab/Dexa | – | 0.56 | 0.92 |
# Plus–minus values are means ± SD.
*P-value for three group comparison of change from baseline (day -2) is provided.
†P-values of difference between treatment groups in change from baseline from linear mixed model.
Interleukin, CRP, c-reactive protein, Dexa, dexamethasone.
IL-6 (pg/ml); CRP (mg/L); D-dimer (ng/ml FEU).