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. 2021 Jul 29;12:643189. doi: 10.3389/fimmu.2021.643189

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Copyright © 2021 Sandgaard, Margetts, Attenborough, Gkouleli, Adams, Holm, Gibb, Gibbons, Giaquinto, De Rossi, Bamford, Palma, Chain, Gkazi and Klein

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in TCR abundance distribution in naïve CD4⁺ T cells during ART treatment interruption. (A, B) The degree of clonal expansion in the TCR repertoire measured using the Gini coefficient in TCRα (blue) and TCRβ sequences (pink) in the PTI (A) and CT (B) group. (C–F) TCR sequence abundance distribution in representative individuals. (C, E) TCRα; (D, F) TCRβ. (C, D) PTI group; (E, F) CT group. TCRβ [pink individual Gini coefficients and dotted lines connecting median(IQR)] and TCRα [blue individual Gini coefficients and solid lines connecting median(IQR)]. *P ≤ 0.05.