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. 2021 Aug 12;11:699749. doi: 10.3389/fonc.2021.699749

Figure 3.

Figure 3

METTL14 regulated PTEN expression in STAD. (A) The potential target site of PTEN modified by METTL14 was predicted by m6A2Target. (B) Correlation analysis between METTL14 and PTEN expression were performed by GEPIA database. (C) PTEN, AKT expression level, and AKT phosphorylation (Ser473) level were detected after METTL14 overexpression in HGC-27 and AGS cells (***P < 0.001). (D, E) Correlation analysis between METTL14 and PTEN mRNA expression in STAD tissue (n = 17); (F, G) Correlation analysis between METTL14 and PTEN protein expression in STAD tissue by IHC (n = 14).