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. 2021 Aug 12;11:699749. doi: 10.3389/fonc.2021.699749

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Copyright © 2021 Yao, He, Gao, Tang, Lin, Yu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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METTL14 inhibits STAD growth and metastasis in vivo. (A) The representative tumors of METTL14 overexpression or negative control HGC-27 cell after transplanting in nude mice. (B) Comparison of tumor volumes of transplanted tumor nude mice between METTL14 overexpression or negative HGC-27 cells. (C) Comparison of metastasis foci in liver of STAD liver metastasis orthotopic tumor models between METTL14 overexpression or negative HGC-27 cells. (D) The representative pictures of HE-stained, Ki67, PTEN and METTL14 expression in STAD subcutaneous xeno transplantation model. (E) The representative pictures of HE-stained, Ki67, PTEN and METTL14 expression in liver metastasis sites of STAD tumor in orthotopic tumor models. (**P < 0.01; ***P < 0.001).