Table 4.
Estimation of Constant Vaccine Efficacy Under Different Reverse-Transcription Polymerase Chain Reaction Testing Schedules When VEh Stays at 80% After Week 6
| Outside Vaccines | Frequency of Tests | Proposed Method | Naive Method | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean (%) | SE (%) | SEE (%) | CP (%) | RE | Mean (%) | SE (%) | SEE (%) | CP (%) | ||
| No | Every day | 79.5 | 3.44 | 3.49 | 95 | 1.36 | 79.5 | 3.44 | 3.46 | 95 |
| Every 2 days | 79.4 | 3.52 | 3.51 | 95 | 1.35 | 79.1 | 3.54 | 3.50 | 94 | |
| Every 4 days | 79.5 | 3.49 | 3.52 | 95 | 1.38 | 78.7 | 3.53 | 3.53 | 93 | |
| Every week | 79.5 | 3.50 | 3.49 | 95 | 1.33 | 77.8 | 3.59 | 3.55 | 90 | |
| Every 2 weeks | 79.5 | 3.58 | 3.60 | 95 | 1.35 | 75.4 | 3.81 | 3.80 | 74 | |
| Yes | Every day | 79.4 | 3.50 | 3.52 | 95 | 1.35 | 79.4 | 3.50 | 3.49 | 95 |
| Every 2 days | 79.5 | 3.48 | 3.53 | 95 | 1.36 | 79.2 | 3.49 | 3.51 | 95 | |
| Every 4 days | 79.5 | 3.58 | 3.56 | 95 | 1.35 | 78.7 | 3.60 | 3.56 | 93 | |
| Every week | 79.5 | 3.53 | 3.52 | 95 | 1.34 | 77.9 | 3.59 | 3.56 | 91 | |
| Every 2 weeks | 79.4 | 3.69 | 3.64 | 95 | 1.35 | 75.7 | 3.85 | 3.79 | 76 |
Mean and SE denote the mean and standard error of the vaccine efficacy (VE) estimator, SEE denotes the mean of the standard error estimator, CP denotes the coverage probability of the 95% confidence interval, and RE is the variance of the VE estimator excluding the infections of the first 6 weeks divided by the variance of the VE estimator using all infections.
Abbreviation: VEh, vaccine efficacy on hazard rate.