Table 1.
A selection of studies evaluating associations between near infrared spectroscopy (NIRS) measured and derived variables with outcome, in intensive care unit (ICU)-treated out-of-hospital cardiac arrest
| First author [ref] | Year | Design | Number of patients | Type of cardiac arrest | Outcome | Principal finding |
|---|---|---|---|---|---|---|
| Meex [14] | 2013 | Observational study | 28 | CA patients treated with TTM | Functional outcome by CPC at hospital discharge | Decrease in rSO2 during induction of TTM. Lower rSO2 levels in patients with poor outcome |
| Storm [15] | 2014 | Observational study | 60 | OHCA and IHCA | Functional outcome at discharge by CPC | Higher NIRS values in patients with good outcome. An rSO2 below 50% appeared associated with poor outcome |
| Ameloot [33] | 2015 | Observational study | 51 | All types of CA | Functional outcome at 180 days by CPC | Disturbed autoregulation more common in patients with chronic hypertension. Time below an autoregulation-derived optimal MAP was negatively associated with outcome |
| Pham [24] | 2015 | Observational study | 23 | OHCA | Functional outcome at 90 days by CPC | No difference in rSO2 in patients, by outcome. Suggestion of disturbed autoregulation in poor outcome patients |
| Bougle [20] | 2016 | Observational study | 43 | OHCA treated with TTM | Functional outcome by CPC on hospital discharge | Mean rSO2 was not different, when indexed by outcome, but the lowest measured was lower in poor outcome patients |
| Genbrugge [16] | 2016 | Observational study | 107 | OHCA | Functional outcome at 180 days by CPC | Slightly higher rSO2 in patients with good outcome. No reliable threshold value was identified |
| Saritas [21] | 2018 | Observational study | 25 | OHCA patients | Functional outcome by CPC on hospital discharge | No difference in rSO2, in patients with good and poor outcome |
| Jakkula [23] | 2019 | Post-hoc analysis of interventional data | 120 | VF arrests with a cardiac cause | Six-month functional outcome by CPC and brain injury assessed with NSE | No association between the mean, median, lowest or highest NIRS value during the first 36 h of ICU care with outcome or the level of NSE at 48 h |
CA cardiac arrest, CPC cerebral performance category, IHCA in-hospital cardiac arrest, MAP mean arterial pressure, NSE neuron specific enolase, OHCA out-of-hospital cardiac arrest, rSO2 regional cerebral oxygen saturation, TTM targeted temperature management, VF ventricular fibrillation