Heding 1984.

Methods	Trial design: Parallel design Randomisation procedure: Data missing Allocation concealment: Unclear Blinding: Double‐blind
Participants	Country: Denmark Setting: Multi centre Number: 67/68 human/animal insulin Type of diabetes: Newly diagnosed type 1 diabetic children Mean age [years]: 37/33 human/animal insulin Mean diabetes duration [years]: 15/14 human/animal insulin Other characteristics:
Interventions	Type of human insulin: Semi‐synthetic Type of animal insulin: Purified porcine Duration of trial [months]: 12
Outcomes	1.HbA1c [%]: ‐ 2.HbA1 [%]: ‐ 3.Fasting plasma glucose [mmol/L] ‐ 4.Insulin dose [Units/day]: ‐ 5.Insulin antibodies [%]: 44 vs 59 (hum. vs anim.) 6.Adverse effects: ‐
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear