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. 2005 Jan 24;2005(1):CD003816. doi: 10.1002/14651858.CD003816.pub2

MacLeod 1995.

Methods Trial design: 
 Crossover study 
 Randomisation procedure: 
 Data missing 
 Allocation concealment: 
 Adequate 
 Blinding: 
 Double‐blind
Participants Country: 
 UK 
 Setting: 
 Single centre 
 Number: 
 40 
 Type of diabetes: 
 Type 1 
 Mean age [years]: 
 30 
 Mean diabetes duration [years]: 
 N/A 
 Other characteristics: 
 Subgroup of patients with longer duration of diabetes
Interventions Type of human insulin: 
 Semi‐synthetic 
 Type of animal insulin: 
 Purified porcine 
 Duration of trial [months]: 
 3
Outcomes 1.HbA1c [%]: 
 ‐ 
 2.HbA1 [%]: 
 8.7±2.0 vs 8.6±2.4 (hum. vs anim.) 
 3.Fasting plasma glucose [mmol/L] 
 ‐ 
 4.Insulin dose [Units/day]: 
 ‐ 
 5.Insulin antibodies [%]: 
 ‐ 
 6.Adverse effects: 
 ‐
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Low risk A ‐ Adequate