| Methods |
Randomised controlled trial, placebo controlled |
| Participants |
43 participants |
| Interventions |
8 day course of adrenocorticotrophic hormone (ACTH) (580 units) |
| Outcomes |
No evidence of efficacy of ACTH on ocular movement after 3 months |
| Notes |
Ocular myasthenia |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
No information on sequence generation |
| Allocation concealment (selection bias) |
Low risk |
Treatment packed at a central office for all participating centres and identified with a randomly assigned code |
| Blinding (performance bias and detection bias)
Observer |
Low risk |
Double blind |
| Blinding (performance bias and detection bias)
Patient |
Low risk |
Double blind |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Missing outcome data balanced in number across intervention groups |
| Selective reporting (reporting bias) |
Low risk |
All expected outcomes are reported |
| Other bias |
High risk |
Number of participants to be included not planned. No clear definition of primary outcome |
