Comparison 2. Lacosamide 600 mg versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Moderate benefit (pain intensity reduction ≥2/10 on NRS or ≥30% on VAS)	2	407	Risk Ratio (M‐H, Fixed, 95% CI)	1.77 [1.34, 2.34]
2 Substantial (pain intensity reduction ≥50% on NRS)	2	407	Risk Ratio (M‐H, Fixed, 95% CI)	1.11 [0.79, 1.56]
3 PGIC much or very much improved	2	408	Risk Ratio (M‐H, Fixed, 95% CI)	1.41 [0.92, 2.14]