Comparison 3. Lacosamide versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 At least one adverse event	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 200 mg	2	392	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.86, 1.06]
1.2 400 mg	5	874	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.99, 1.17]
1.3 600 mg	3	594	Risk Ratio (M‐H, Fixed, 95% CI)	1.11 [1.01, 1.21]
2 Serious adverse events	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 200 mg	2	392	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.25, 1.43]
2.2 400 mg	5	1304	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.66, 1.57]
2.3 600 mg	3	594	Risk Ratio (M‐H, Fixed, 95% CI)	1.39 [0.74, 2.59]
3 All‐cause withdrawals	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 200 mg	2	392	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.72, 1.37]
3.2 400 mg	5	874	Risk Ratio (M‐H, Fixed, 95% CI)	1.26 [1.03, 1.55]
3.3 600 mg	3	594	Risk Ratio (M‐H, Fixed, 95% CI)	2.09 [1.65, 2.65]
4 Lack of efficacy withdrawals	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 200 mg	2	392	Risk Ratio (M‐H, Fixed, 95% CI)	1.30 [0.40, 4.26]
4.2 400 mg	5	874	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.34, 1.19]
4.3 600 mg	3	594	Risk Ratio (M‐H, Fixed, 95% CI)	1.37 [0.57, 3.30]
5 Adverse event withdrawals	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 200 mg	2	392	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.51, 1.66]
5.2 400 mg	5	874	Risk Ratio (M‐H, Fixed, 95% CI)	2.01 [1.39, 2.91]
5.3 600 mg	3	594	Risk Ratio (M‐H, Fixed, 95% CI)	3.80 [2.47, 5.82]