7. Measures of coagulation: fibrinogen concentration.

	FFP	Comparator
Kasper 2001 ‐ fibrinogen concentration after FFP (or comparator) infusion*	1.8 g/l ± 0.5 g/l (n = 27)	1.3 g/l ± 0.4 g/l (n = 29)
Lee 2013 ‐ fibrinogen concentration after protamine administration: infants*	1.70 g/l ± 0.422 g/l (n = 26)	1.129 g/l ± 0.295 g/l (n = 28)
Lee 2013 ‐ fibrinogen concentration after protamine administration: children (aged 1 to 16 years)**	1.54 g/l (1.388 to 1.933 g/l) (n = 34)	1.36 g/l (1.163 to 1.583 g/l) (n = 33)
McCall 2004 ‐ fibrinogen concentration after end of cardiopulmonary bypass*	1.23 g/l ± 0.2 g/l (n = 10)	0.58 g/l ± 0.17 g/l (n = 10)
Oliver 2003 ‐ fibrinogen concentration 10 minutes after protamine administration*	0.996 g/l ± 0.398 g/l (n = 28)	0.681 g/l ± 0.289 g/l (n = 28)
Snow 1982 ‐ fibrinogen concentration in recovery room postoperatively*	2.58 g/l ± 0.87 g/l (n = 26)	2.45 g/l ± 0.64 g/l (n = 27)

*Data reported as mean±standard deviation. 
**Data reported as median (interquartile range).

FFP: fresh frozen plasma