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. 2015 Jul 14;2015(7):CD007614. doi: 10.1002/14651858.CD007614.pub2

Comparison 1. Fresh frozen plasma versus no plasma.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Short‐term mortality (up to 30 days) 6   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
1.2 Serious organ damage ‐ myocardial infarction 1 120 Risk Ratio (M‐H, Random, 95% CI) Not estimable
1.3 Serious organ damage ‐ renal failure 1   Mean Difference (IV, Random, 95% CI) Totals not selected
1.4 Bleeding in first 24 hours (adults ‐ ml; neonates and paediatrics ml/kg) 4   Mean Difference (IV, Random, 95% CI) Subtotals only
1.4.1 Neonates and paediatrics 4 138 Mean Difference (IV, Random, 95% CI) ‐1.46 [‐4.70, 1.78]
1.5 Transfusion requirements (volume) – red cells (up to 24 hours) (adults ‐ ml; neonates and paediatrics ml/kg) 3   Mean Difference (IV, Random, 95% CI) Subtotals only
1.5.1 Neonates and paediatrics 3 110 Mean Difference (IV, Random, 95% CI) 0.40 [‐2.99, 3.79]
1.6 Number of patients receiving a red cell transfusion 4 222 Peto Odds Ratio (Peto, Fixed, 95% CI) 2.57 [1.30, 5.08]
1.7 Transfusion requirements – platelets (up to 24 hours) (units) 2   Mean Difference (IV, Random, 95% CI) Totals not selected
1.7.1 Neonates and paediatrics 2   Mean Difference (IV, Random, 95% CI) Totals not selected
1.8 Transfusion requirements – cryoprecipitate (up to 24 hours) (units) 2   Mean Difference (IV, Random, 95% CI) Totals not selected
1.8.1 Neonates and paediatrics 2   Mean Difference (IV, Random, 95% CI) Totals not selected
1.9 Measurement of prothrombin time within 2 hours of FFP or control infusion 5 210 Mean Difference (IV, Fixed, 95% CI) ‐0.71 [‐1.28, ‐0.13]
1.10 Measurement of activated partial thromboplastin time within 2 hours of FFP or control infusion 8   Mean Difference (IV, Random, 95% CI) Totals not selected
1.11 Measurement of fibrinogen concentration within 2 hours of FFP or control infusion 5   Mean Difference (IV, Random, 95% CI) Totals not selected
1.12 Resource use: time in intensive care unit 2   Mean Difference (IV, Random, 95% CI) Totals not selected
1.13 Resource use: need for return to theatre 7 398 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.81 [0.26, 2.57]