Characteristic Study ID	Intervention(s) [route, frequency, total dose/day]	Detailed chemical content of (daily) intervention [mg]	Control(s) [route, frequency, total dose/day]	All other weight loss interventions, such as exercise or diet, that participants may be using	Caffeine content [mg/d]
Auvichayapat 2008	Oral, 3 capsules/d (1 after each meal); total daily dose: 140.85 mg catechins 750 mg green tea extract (Herbal One brand)	Caffeine 86.58 Total catechins 140.85 Catechin 12.27 Epicatechin gallate 27.84 Epigallocatechin gallate 100.74 also: gallic acid 0.72 daily – "gallate is a salt or ester of gallic acid"	Oral, 3 capsules/d; total daily dose of 0 mg catechins	Note: participants consumed a regular diet (total energy, 8373.6 kJ/d) prepared by the Nutrition Unit of Srinagarind Hospital; participants were asked to maintain their regular exercise regimen	I1: 86.58 C1: 0
Diepvens 2005	Oral, 9 capsules/d (3 capsules at breakfast, lunch + dinner); total daily dose: 1206.9 mg catechins/d and 236.7 mg caffeine/d	Caffeine 236.7 Total catechins 1206.9 Catechin 31.5 Epicatechin  126 Gallocatechin 0 Epigallocatechin 240.3 Catechin gallate  0 Epicatechin gallate 212.4 Gallocatechin gallate 0 Epigallocatechin gallate 595.8	Oral, 9 capsules/d (3 capsules at breakfast, lunch + dinner); total daily dose of 0 mg catechins	I1: d 1‐3: standardised energy balance diet; d 4 to 87 low‐energy diet consumed (meal replacement diet plan of Slim‐Fast shake, soup, bar or pasta) at breakfast and lunch, and instructions about food allowed for dinner and snacks C1: d 1 to 3: standardised energy balance diet; d 4 to 87 low‐energy diet consumed (meal replacement diet plan of Slim‐Fast shake, soup, bar or pasta) at breakfast and lunch, and instructions about food allowed for dinner and snacks	I1: 236.7 in 9 capsules + 300 mg/d (from coffee) = 536.7 mg C1: 300 mg/d (from coffee) Note: daily caffeine intake standardised for all participants to 300 mg/d
Hill 2007	Oral, 2 capsules/d (1 before breakfast, 1 before evening meal on non‐exercise days; on exercise d 1 of the 2 capsules taken 1 h before exercise); total daily dose: 300 mg catechins	Caffeine 0 Total catechins 300 Epigallocatechin gallate 300	Oral, 2 capsules/d (1 before breakfast, 1 prior to evening meal on non‐exercise days; on exercise d 1 of the 2 capsules taken 1 h before exercise); total daily dose of 0 mg catechins	I1:  run/walk for 45 min, 3 times/wk at HR corresponding to 75% of age predicted maximum in a protocol described previously C1: run/walk for 45 min, 3 times/wk at HR corresponding to 75% of age predicted maximum in a protocol described previously	‐ *Note: participants excluded if they consumed ≥ 3 cups of green tea/d or had habitual caffeine intake of ≥ 300 mg (> 3 or 4 cups) from coffee/d
Hsu 2008	Oral, 3 capsules/d (30 minutes after meals); total daily dose: 613.5 mg catechins	Caffeine 27.3 Total catechins 613.5 Catechin 8.28 Epicatechin  70.33 Gallocatechin 61.58 Epigallocatechin 36.91 Catechin gallate 0 Epicatechin gallate 31.76 Gallocatechin gallate 27.48 Epigallocatechin gallate 377.15	Oral, 3 capsules/d; total daily dose of 0 mg catechins	Note: no other obesity management allowed; participants asked to maintain former diet during study period	I1: 27.3 C1: 0
Hursel 2009	I1: oral, 6 capsules/d (2 before each meal); total daily dose: 270 mg EGCG + 150 mg caffeine I2: oral, 6 capsules/d (2 before each meal); total daily dose: 270 mg EGCG + 150 mg caffeine	Caffeine 150 Total catechins 270 Epigallocatechin gallate 270	C1: oral, 6 capsules/d; total daily dose of 0 mg catechins C2: oral, 6 capsules/d; total daily dose of 0 mg catechins	I1: AP diet (50‐60 g protein as 50 g calcium caseinate powder; ˜10% of energy from protein) I2: HP diet (100‐110 g protein as 50 g increments of calcium caseinate powder; ˜20% of energy from protein) C1: AP diet, same as I1 group C2: HP diet, same as I2 group	I1: 150 I2: 150 C1: 0 C: 0 *Note: participants were allowed up to 100 mg caffeine/d from other sources
Kajimoto 2005	I1: oral, 250 mL catechin drink twice/d (at breakfast and dinner), placebo drink once daily at lunch; total daily dose: 444.3 mg catechins + 50.2 mg caffeine I2: oral, 250 mL catechin drink 3 times/d at mealtimes; total daily dose: 665.9 mg catechins + 49.2 mg caffeine	Low dose group numbers followed by high dose group numbers: I1 (I2) Caffeine  50.2 (49.2) Total catechins  444.3 (645.9)   Catechin  2.9 (2.7) Epicatechin 3.6 (4.8) Gallocatechin 3.6 (3.3) Epigallocatechin 3.9 (2.1) Catechin gallate 51.7 (73.5) Epicatechin gallate 68.2 (102.3) Gallocatechin gallate 158.1 (233.4) Epigallocatechin gallate 152.3 (223.8)	Oral, 250 mL bottle 3 times/d at mealtimes; total daily dose of 41.1 mg catechins/d + 52.2 mg caffeine	Note: participants instructed not to change usual routine	I1: 50.2 mg I2: 49.2 mg C1: 52.2 mg
Kataoka 2004	I1: oral, 500 mL once/d; total daily dose of 277.9 mg catechins I2: oral, 500 mL once/d; total daily dose of 570.4 mg catechins I3: oral, 500 mL once/d; total daily dose of 844.7 mg catechins (also contained sweeteners, acidulants, electrolytes, antioxidants, and flavouring)	Caffeine < 40 mg Total catechins Low/Med/High 277.9/570.4/844.7                                Catechin 8.2/12.7/24.7 Epicatechin 24.7/49.7/73.9 Gallocatechin 17.7/36.0/53.4 Epigallocatechin 80.6/174.7/253.3 Catechin gallate 2.8/4.1/8.6 Epicatechin gallate 35.0/65.7/103.9 Gallocatechin gallate 3.3/9.1/11.1  Epigallocatechin gallate 105.6/218.4/315.8	Oral, 500 mL once/d; total daily dose of 0 mg catechins (also contained sweeteners, acidulants, electrolytes, antioxidants, and flavouring)	Note: diet and food intake adjusted to constant levels; pedometer used to measure steps daily	I1: < 40 mg/d from beverage I2: < 40 mg/d from beverage I3: < 40 mg/d from beverage C1: < 40 mg/d from beverage Note: participants not allowed to consume catechin‐containing tea or caffeinated coffee beverages during study, or any food supplement that might affect energy metabolism (263)
Kovacs 2004	Oral, 6 capsules/d (2 with breakfast, lunch + dinner); total daily dose: 572.76 mg catechins + 103.5 mg caffeine	Caffeine 103.5 Total catechins  572.76 Catechin 6.06 Epicatechin 34.56 Gallocatechin 6.66 Epigallocatechin 22.62 Catechin gallate 4.86 Epicatechin gallate 124.44 Gallocatechin gallate 50.7 Epigallocatechin gallate 322.86	Oral, 6 capsules/d (2 with breakfast, lunch + dinner); total daily dose of 0 mg catechins	I1: none C1: none Note: weight loss intervention used in 4‐week run‐in phase	I1: 103.5 mg caffeine C1: 0 Note: habitual caffeine consumption of GT group was 369 (227) mg/d, with a range of 1 to 991 mg/d (N = 19 with < 300 mg caffeine/d; N = 32 with > 300 mg caffeine/d) Habitual caffeine consumption of placebo group was 358 (190) mg/d, with a range of 39 to 996 mg/d (N n= 19 with < 300 mg caffeine/d; N = 32 with > 300 mg caffeine/d)
Kozuma 2005	Oral, 500 mL once/d; total daily dose of 539.7 mg catechins	Caffeine ‐ Total catechins  539.7 Catechin 14.0 Epicatechin 47.5 Gallocatechin 35.1 Epigallocatechin 166.9 Catechin gallate 8.3 Epicatechin gallate 58.9 Gallocatechin gallate 7.6 Epigallocatechin gallate 201.4	Oral, 500 mL once/d; total daily dose of 0 mg catechins	Note: participants were assisted by head physicians to maintain regular food intake and exercise Medications, special health products, supplements or dietary foods that might affect metabolism of sugar, fat, or energy were restricted Intake of fat was not restricted	‐
Maki  2009	Oral, 500 mL once/d; total daily dose: 625 mg catechins (also contains water, sodium chloride, artificial citrus flavouring, glucose, erythritol, and sucralose; 15 kcal of energy and 250 mg of sodium)	Caffeine 39.5 Total catechins 625 Catechin 19.2 Epicatechin 53.9 Gallocatechin 51.8                  Epigallocatechin 207.5 Catechin gallate 6.0 Epicatechin gallate 56.5 Gallocatechin gallate 15.4 Epigallocatechin gallate 214.4	Oral, 500 mL once/d; total daily dose of 0 mg catechins (containing water, sodium chloride, artificial citrus flavouring, glucose, erythritol, and sucralose; 15 kcal of energy and 250 mg of sodium)	I1: exercise programme (at least 3 supervised exercise sessions per week with goal of ≥ 180 min/wk of moderate‐intensity physical activity) C1: exercise programme (at least 3 supervised exercise sessions per week with goal of ≥ 180 min/wk of moderate‐intensity physical activity)	I1: ˜ 39 C1: ˜ 39     Note: participants agreed: to record all caffeinated beverages consumed not to consume > 2 caffeinated beverages/d not to consume over the counter supplements containing caffeine not to consume any medications containing caffeine
Nagao 2007	Oral, 340 mL once/d; total daily dose: 582.76 mg catechins, within 1 h of evening meal (steeped green tea used as base for both I and C)	Caffeine 72.42 Total catechins 583.1 Catechin  42.84 Epicatechin 32.3 Gallocatechin 127.5 Epigallocatechin 69.36 Catechin gallate 40.12 Epicatechin gallate 30.94 Gallocatechin gallate 139.74 Epigallocatechin gallate 100.3	Oral, 340 mL once/d; total daily dose: 96.3 mg catechins, within 1 h of evening meal (steeped green tea used as base for both I and C)	Note: medications known to influence lipid or carbohydrate metabolism were prohibited	I1: 72.42 C1: 75.14 Note: tea and coffee were not limited though trial
Suzuki 2009	Oral, 340 mL twice/d (1 with breakfast, 1 with dinner); total daily dose: 392.2 mg catechins + 85.4 mg caffeine	Caffeine  85.4 Total catechins 392.2 Catechin 0 Epicatechin 0 Gallocatechin 35.8 Epigallocatechin 16.6 Catechin gallate 31 Epicatechin gallate 45.2 Gallocatechin gallate 135.4 Epigallocatechin gallate 128.2	Oral, 340 mL twice/d (1 with breakfast, 1 with dinner); total daily dose: 65.4 mg catechins + 93 mg caffeine	Note: directed to maintain usual lifestyle patterns: Get adequate sleep Avoid excessive eating/drinking Avoid strenuous exercise Participants given identical meals to consume: Breakfast and dinner 2 and 3 d before examinations Breakfast, lunch and dinner the day before examinations	I1: 85.4 C1: 93
Takase 2008	Oral, 500 mL once/d; total daily dose: 539.7 mg catechins	Caffeine 40 mg Total catechins  539.7 Catechin 14.0 Epicatechin 47.5 Gallocatechin 35.1 Epigallocatechin 166.9 Catechin gallate 8.3 Epicatechin gallate 58.9 Gallocatechin gallate 7.6 Epigallocatechin gallate 201.4	Oral, 500 mL once/d; total daily dose of 0 mg catechins	Note: participants were instructed to maintain diet and exercise levels, avoiding change	I1: 40 C1: 0
Takashima 2004	Oral, 500 mL once/d; total daily dose: 570.4 mg catechins	Caffeine < 40 Total catechins  570.4 mg Catechin 12.7 Epicatechin 49.7 Gallocatechin 36.0 Epigallocatechin  174.7 Catechin gallate  4.1 Epicatechin gallate  65.7 Gallocatechin gallate  9.1 Epigallocatechin gallate  218.4	Oral, 500 mL once/d; total daily dose of 0 mg catechins	Note: participants were instructed to maintain diet and exercise levels, avoiding change	I1: < 40 mg/d (stated that beverage contained < 8 mg/100 mL) C1: < 40 mg/d (stated that beverage contained < 8 mg/100 mL) Note: during the study participants were not allowed to consume any tea with catechins or coffee with caffeine
Takeshita 2008	Oral, 500 mL once/d; total daily dose: 548 mg catechins	Caffeine 0 Total catechins  547.5 Catechin 17.5 Epicatechin 50.5 Gallocatechin 39.5 Epigallocatechin 282 Catechin gallate 0 Epicatechin gallate 18.5 Gallocatechin gallate 7 Epigallocatechin gallate 132.5	Oral, 500 mL once/d; total daily dose of 0 mg catechins	Note: foods or medicines that would affect the metabolism of fat or sugar prohibited; participants asked to maintain previous level of physical fitness	I1: 0 C1: 0 Note: tea beverages with catechins or caffeine prohibited; coffee with caffeine restricted to 2 cups/d maximum
Tsuchida 2010	Oral, 340 mL once/d; total daily dose of 587.52 mg catechins and 82.96 mg caffeine	I1/C1: Caffeine 82.96/81.26  Total catechins 587.52/126.82 Catechin 39.44/7.82 Epicatechin 27.54/4.76 Gallocatechin 134.30/31.96 Epigallocatechin 79.56/18.70 Catechin gallate 34.68/ 5.78 Epicatechin gallate 30.60/5.44 Gallocatechin gallate 126.48/27.2 Epigallocatechin gallate 114.92/25.16	Oral, 340 mL once/d; total daily dose of 126.82 mg catechins and 81.26 mg caffeine	Note: participants were to maintain usual levels of food intake and exercise as much as possible   Food products that might affect energy absorption (e.g. dietary fibre supplements, psyllium) were restricted, as were medications that affect lipid metabolism	I1: 82.96 mg C1: 81.26 mg
Wang 2010	I1: oral, 250 mL twice/d; total daily dose of 458 mg catechins and 104 mg caffeine I2: oral, 250 mL twice/d; total daily dose of 468 mg catechins and 126 mg caffeine I3: oral, 250 mL twice/d; total daily dose of 886 mg catechins and 198 mg caffeine All drinks consumed at least 4 h apart, following a meal: breakfast before first treatment, and lunch or dinner before second treatment	Caffeine GT1: 104 GT2: 126  GT3: 198 Total catechins GT1: 458 GT2: 468  GT3: 886	Oral, 250 mL twice/d; total daily dose of 30 mg catechins and 10 mg caffeine All drinks were consumed at least 4 h apart, and following a meal: breakfast before first treatment, and lunch or dinner before second treatment	Note: participants were not to consume other beverages with catechins or caffeine. Participants were asked to use the same mode of transportation to reach the research facility during the study period	I1: 104 I2: 126 I3: 198 C1: 10 Note: no other sources of caffeine were allowed
Westerterp‐ Plantenga 2005	I1: oral, 6 capsules/d (2 capsules before each meal) total daily dose: 270 mg EGCG + 150 mg caffeine I2: oral, 6 capsules/d (2 capsules before each meal) total daily dose: 270 mg EGCG + 150 mg caffeine	Caffeine 150 Total catechins 270 Epigallocatechin gallate 270	C1: oral, 6 capsules/d; total daily dose of 0 mg catechins C2: oral, 6 capsules/d; total daily dose of 0 mg catechins	‐	I1: 150 mg + low habitual caffeine consumption I2: 150 mg + high habitual caffeine consumption C1: 0 + low habitual caffeine consumption C2: 0 + high habitual caffeine consumption
Footnotes "‐" denotes not reported AP: adequate protein; C: control; EGCG: epigallocatechin‐3‐gallate ; GT: green tea; HP: high protein; HR: heart rate; I: intervention