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. 2021 Aug 31;22:633. doi: 10.1186/s12864-021-07939-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Diversity and genomic context of CylC-like enzymes BGCs. a Examples of the different BGC architectures found among the clusters encoding CylC homologs. b Genome Neighborhood Diagram (GND) depicting the Pfam domains associated with each cluster from the initial SSN of CylC homologs. The size of each node is proportional to the prevalence of the Pfam domain within the genomic context of the CylC homologs from each SSN cluster. c RAxML cladogram (1000 replicates, shown are bootstrap values > 70 %) of CylC homologs. The different colors represent a categorization based on common genes found within the associated biosynthetic gene clusters (see legend). Some BGCs contain more than one cylC homolog: circles of the same color depict different CylC homologs encoded in the same BGC. AurF (Streptomyces thioluteus HKI-22) was used as an outgroup