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. 2021 Aug 31;22:633. doi: 10.1186/s12864-021-07939-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Prevalence of putative cyanobacterial halogenases. Frequency of halogenase homologs in Cyanobacteria from CORASON analysis (a) and NCBI BLASTp analysis (a). Dimetal-carboxylate halogenases: CylC - NCBI reference genomes, n = 2054 and LEGEcc genomes, n = 41 CylC-containing BGCs and 56 genomes; Flavin-dependent halogenases: PrnA - NCBI reference genomes, n = 2051 and LEGEcc genomes, n = 56 genomes; Bmp5- NCBI reference genomes, n = 2050 and LEGEcc genomes, n = 56 genomes; McnD: NCBI reference genomes, n = 2052 and LEGEcc genomes, n = 54 genomes; Nonheme iron/2OG-dependent halogenases: halogenase domain from CurA - NCBI reference genomes, n = 2052 and LEGEcc genomes, n = 56 genomes. B Average of the total number of homologs per dimetal-carboxylate halogenases (CylC, BrtJ, “Mic”, ColD, ColE, NocO, NocN), flavin-dependent halogenases (PrnA, Bmp5 and McnD) and nonheme iron/2OG-dependent halogenases (Barb1, HctB, WelO5, AmbO5 and the halogenase domain from CurA)