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The many roles of circRNAs in HCC. CircRNAs can affect cell proliferation and tumorigenesis in HCC progression. CircRNAs are involved in the epithelial-to-mesenchymal transition (EMT) process, exerting important functions in HCC cell invasion and metastasis. CircRNAs can also affect HCC development and prognosis by regulating the immune system. Some circRNAs may even play a vital role in the induction and maintenance of drug resistance during HCC drug treatment
