Table 1.

Overview of dysregulated circRNAs in hepatocellular carcinoma (HCC)

circRNAs	Dysregulation	Sponge targets	Downstream genes/proteins	Phenotype	References
circCDYL	Up	miR-892a miR-328-3p	HDGF/HIF1AN	Proliferation (+)	[39]
circSLC3A2	Up	miR-490-3p	PPM1F	Proliferation (+)	[40]
circFBLIM1	Up	miR-346	FBLIM1	Proliferation (+)	[41]
circHIPK3	Up	miR-124	AQP3	Proliferation (+)	[42]
circZNF566	Up	miR-4738-3p	TDO2	Proliferation (+)	[43]
circMAT2B	Up	miR-338-3p	PKM2	Proliferation (+); Metastasis (+)	[44]
circASAP1	Up	miR-326 miR-532-5p	MAPK1 CSF-1	Proliferation (+); Metastasis (+)	[37]
circDYNC1H1	Up	miR-140-5p	SULT2B1	Proliferation (+)	[45]
circARFGEF2	Up	miR-143-3p PCBP1	FOSL2 CD44v6	Proliferation (+); Metastasis (+)	[46]
circMAST1	Up	miR-1299	CTNND1	Proliferation (+)	[47]
circBACH1	Up	–	p27 HuR	Proliferation (+)	[48]
circRHOT1	Up	–	TIP60 NR2F6	Proliferation (+); Metastasis (+)	[49]
circβ-catenin	Up	–	β-catenin-370aa (circβ-catenin’s translation product)	Proliferation (+); Metastasis (+)	[50]
circUHRF1	Up	miR-449c-5p	TIM-3	Proliferation (+); Metastasis (+); Drug resistance (+); Immunity (−)	[51]
circSORE	Up	miR-103a-2-5p miR-660-3p	Wnt2b	Drug resistance (+)	[52]
circSORE	Up	–	YBX1	Drug resistance (+)	[53]
circMET	Up	miR-30-5p	CXCL10	Drug resistance (+); Immunity (−)	[54]
circUBAP2	Up	miR-194-3p	MMP9	Proliferation (+); Metastasis (+)	[59]
circPABPC1	Down	–	ITGB1	Proliferation (−); Metastasis (−)	[60]
circADD3	Down	–	EZH2 CDK1	Proliferation (−); Metastasis (−)	[55]
circMTO1	Down	miR-9	P21	Proliferation (−)	[56]
circSETD3	Down	miR-421	MAPK14	Proliferation (−)	[57]
circSMARCA5	Down	miR-17-3p miR-181b-5p	TIMP3	Proliferation (−)	[36]
circZKSCAN1	Down	–	FMRP CCAR1	Proliferation (−); Metastasis (−)	[58]