Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 30;21:461. doi: 10.1186/s12935-021-02175-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Avasimibe-induced inhibition of cell migration and proliferation was partially rescued by E2F-1 knockdown. a qRT-PCR affirmed the interfering efficiency of E2F-1 in PCa cells (DU 145, PC-3); b MTT assays showed that inhibition of cell proliferation was partially rescued by E2F-1 knockdown in DU 145 cells; c results of MTT assays in PC-3 cells; d clonogenic survival assays showed that inhibition of colony formation was partially rescued by E2F-1 knockdown in DU 145 and PC-3 cells; e the quantitative results of clonogenic survival assays; f Transwell assays revealed that inhibition of cell migration could be rescued by E2F-1 knockdown; g statistical analysis of the results of transwell assays; h western blots of the EMT-related protein N-cadherin, Vimentin, E-cadherin and Snail in DU 145 and PC-3 cells after avasimibe treatment and E2F-1 knockdown; i mechanism diagram. *p < 0.05, **p < 0.01, ***p < 0.001, the scale bar is 1 cm