Boscia 1987.

Methods	Study design: parallel RCT Duration of study: July 1983 to July 1985 Duration of follow‐up: 6 months
Participants	Country: USA Setting: geriatric centre Inclusion criteria: elderly ambulatory women capable of giving a midstream clean‐catch urine specimen Definition of ASB: ≥ 100,000 CFU/mL urine specimens twice within one week, same pathogen Number: treatment group (63); control group (61) Mean age ± SE (years): treatment group (85.8 ± 0.9); control group (85.8 ± 0.7) Sex (M/F): all women Exclusion criteria: indwelling catheter; unable to care for themselves
Interventions	Treatment group Initial treatment (depending on susceptibility of pathogen) TMP: 200 mg single dose Cefaclor 500 mg 3 times/d for 3 days Retreatment (for failure) TMP: 200 mg twice/d for 14 days Cefaclor: 500 mg 3 times/d for 14 days Control group No treatment
Outcomes	Morbidity Mortality Bacteriological cure Definition of bacteriological cure: < 10,000 CFU/mL
Notes	Urine culture 2 weeks post treatment and at 6 months Most E. coli Monitored for symptoms, mortality, adverse events, antibiotic treatment, bladder catheterization
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomised from code numbers prior to urine culture
Allocation concealment (selection bias)	Low risk	Assigned by an individual not associated with the study
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Single blind
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	Exclusions, drop‐out described: treatment group (died (2); incontinent (3); moved away (2); refused (1)); control group (3 died (3); incontinent (2); refused (1))
Selective reporting (reporting bias)	Low risk	Not observed
Other bias	Low risk	Not observed