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. Author manuscript; available in PMC: 2021 Aug 31.
Published in final edited form as: Curr Alzheimer Res. 2019;16(13):1163–1174. doi: 10.2174/1567205016666191121142558

Table 3.

Top 10% genes in all four topological centralities.

Gene Betweenness Closeness PageRank Degree
APP 0.28 0.50 0.04 0.22
HSP90AA1 0.23 0.47 0.04 0.19
PARK2 0.19 0.49 0.03 0.18
NRF1 0.12 0.41 0.03 0.15
ELAVL1 0.10 0.42 0.02 0.14
RNF2 0.05 0.40 0.02 0.10

Betweenness: betweenness centrality, denotes the number of short communication paths that a node participates in; Closeness: closeness centrality, corresponds to the average distance (the length of the shortest paths) between a given node and the rest of the network; PageRank: PageRank centrality, takes into account the quantity and quality of connections to a given node; Degree: degree centrality, counts the number of interactions with a given node.