DRKS00013158 2017.

Study name	Influence of perinterventional acupuncture on the incidence of postoperative delirium after elective, endoprosthetic replacement of the hip joint
Methods	Randomised controlled trial
Participants	135 patients (≥ 65 years) scheduled for total endoprosthetic hip
Interventions	Group 1: acupuncture Group 2: control (no treatment)
Outcomes	Primary outcome: incidence of postoperative delirium after total hip joint replacement at 24 hours and 48 hours postoperatively using the CAM for intensive care units. Secondary outcome: activity of acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE) in the blood, Determination TNFa, NSE, S‐100 ß protein, Epigenetic markers such as DNA methylation, acetylation, and histone modifications, hospital length of stay. All measured 4 times (during premedication, directly postoperatively, first and second postoperatively)
Starting date	01/01/2018
Contact information	Lars Bergmann, lars.bergmann@kk‐bochum.de. Universitätsklinikum Knappschaftskrankenhaus Bochum, Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie
Notes	German Clinical Trials Register, Main ID: DRKS00013158 Status: recruiting planned